Inovio Pharmaceuticals, Inc. (INO) Citizens JMP Life Sciences Conference (Transcript)


Inovio Pharmaceuticals, Inc. (NASDAQ:INO) Citizens JMP Life Sciences Conference May 8, 2025 11:30 AM ET

Company Participants

Jacqui Shea – President and CEO
Mike Sumner – Chief Medical Officer

Conference Call Participants

Roy Buchanan – JMP

Roy Buchanan

All right. Thank you again, everybody, for joining us here at the Citizens Life Sciences Conference. So next company we have is exciting, Inovio Pharmaceuticals. I think they’re still on track to have the first DNA immunotherapy approved in the US, mRNA gets a lot of attention or has gotten a lot of attention but there’s some very differentiating aspects of DNA. I think most recently demonstrated with their DMAb monoclonal antibody durability data that we’ll hopefully get into. But we’re happy to have, CEO, Dr. Jacqui Shea; and Dr. Mike Sumner, Chief Medical Officer, here to present the story. So maybe Jacqui let’s — and Mike start, just briefly review the platform and how it differs from these other platforms like mRNA or viral platforms, maybe how broad you can go with DNA?

Jacqui Shea

Yes. Great question, Roy. And thanks very much for the invitation, nice to be here today. So when you think about DNA medicines and RNA medicines, they’re both nucleotide based therapies. There are actually quite a lot of differences between the two platforms. So the mRNA molecules are inherently more unstable than DNA. DNA is much more stable and they’re also delivered in different ways. So mRNA requires lipid nanoparticles for delivery and to protect the mRNA from degradation. Whereas with DNA, we use our proprietary delivery systems called CELLECTRA. So mRNA can be quite dependent on ultracold chain for distribution, DNA being much more stable. We don’t require any frozen shipping or storage. And then when you think about the kinds of immune responses that mRNA generates versus the DNA medicines platform, mRNA is very good at generating very high — ultrahigh levels of



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'Sirens' Series: Release Date, Where to Watch, Cast & More
Image Credit: COURTESY OF NETFLIX

Sirens has broken the sound barrier already among television viewers. With a cast featuring a few of Hollywood’s biggest stars — Julianne Moore and Kevin Bacon to name a few — the miniseries has become a hot and spicy hit! And now that the cast has appeared at an official red carpet premiere for it, TV fans are wondering what’s so enticing about the show.

Below, Hollywood Life has all the details you need to know about the latest hit show Sirens.

When Was Sirens Released to Streaming?

Sirens was released on May 22, 2025.

Where to Watch Sirens

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'Sirens' Series: Release Date, Where to Watch, Cast & More
Courtesy of Netflix © 2025

Who Is in the Sirens Cast?

Julianne leads the show as the character Michaela a.k.a “Kiki,” a billionaire boss and a former lawyer. The rest of the main cast includes Meghann Fahy as Devon DeWitt, Milly Alcock as Simone DeWitt, Glenn Howerton as Ethan Corbin III, Bill Camp as Bruce DeWitt, Felix Solis as Jose and Kevin as Peter Kell.

Since Kevin plays the husband of Michaela (Julianne), the veteran actor opened up about his character during an interview with Netflix’s Tudum ahead of the series’ May 2025 release.

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“I don’t love all the characters that I’ve played, but I have to understand their point of view on some level,” the Footloose actor pointed out. “A couple of times I played actual monsters, but I think of them as human beings. If they’re actual monsters, they’re actual monsters, but when I’m playing a man, regardless of what it is that he does, I have to just figure out a way that he is in some way justified — or maybe not justified, but in some ways it’s human, just human. That’s it.”



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